BJRP 011204

ANTIBODIES AGAINST DENGUE VIRUS: WHICH ONES ARE EFFECTIVE AGAINST THIS NEGLECTED DISEASE AND WHY? SEARCHING FOR CORRELATIONS BETWEEN STRUCTURAL DYNAMICS AND IMMUNOLOGICAL PROPERTIES OF ANTIBODYANGIEN COMPLEXES

Abstract

Our complementary expertise will be applied to Dengue virus, a neglected disease causing 500,000 hospitalizations and 20,000 deaths per year. Our ai mis to compare the binding of antibodies that recognizes  the surface protein of the four Dengue serotypes, searching for correlations between immunological, structural, dynamics and binding properties, to further our understanding of antibody/antigen interaction as well as a basis for drug design and improved vaccine strategies.


Dr. Luca VARANI
Prof. Ana P. VALENTE